PL2543 USB 2.0 to 4-port Full UART Controller

Single-chip upgrade solution for Legacy

RS232 devices to USB interface

USB to RS232/RS422/RS485 interface converters/cables/dongles/adapters

MCU-based devices to USB host interface

Point-of-Sale (POS) Terminals/Printers/Pole Displays

USB Barcode/Smart Card Readers

PC I/O Docking Station/Port Replicators

Healthcare/Medical USB Interface Data Transfer Cable

Serial-over-IP Wireless Solution

Cellular/PDA USB Interface Data Transfer Cable

GPS/Navigation USB Interface

Industrial / Instrumentation / Automation Control USB Interface

USB Modem / Wireless / Zigbee USB Interface

Set-Top Box (STB) / Home Gateway USB Interface

Battery Charger Detection for high-current and quick charging of batteries.


UART Interface

Support 4-port full UART interface

Individual 4-port full UART interface

RS232, RS422, RS485

Up to 24Mbps flexible baud rate

5, 6, 7, or 8 data bits

Odd, Even, Mark, Space, None parity mode

One, one and half, or two stop bits

Hardware flow control (CTS/RTS and/or DSR/DTR)

Software flow control (XON/XOFF)

Configurable remote wakeup pin

Individual 512bytes FIFO for IN/OUT buffer per port

Configurable threshold of flow control

Configurable transmit and receive LED pins

Configurable invert option of UART signals

Suspend pin control for RS232 transceiver

PL2543 data sheet


PL2543 data sheet

Driver for Windows

Download 2023/05/15 v3.1.0.0 11326.73KB
Windows Driver Installer Setup Program ( Win7 / Win8.1 / Win10 / Win11)
Installer version & Build date: v3.1.0.0 (2023-05--05) Windows 11 ( 64-bit ) WDF WHQL Driver: v7.1.3.0 (12/22/2022) / v4.1.4.0 (03/23/2023) (For PL2543 / PL2523 / PL2565 / PL2502 / PL2503 versions) - Windows 11 Certified WHQL Driver ( 22H2 versions) - Auto-download driver via Windows Update (Windows 11) Windows 7/8.1/10 (32 & 64-bit) WDF WHQL Driver: v7.0.2.0 (12/15/2022) / v4.0.4.0 (03/15/2023) (br) (For PL2543 / PL2523 / PL2565 / PL2502 / PL2503 versions)
- Windows 10 Certified WHQL Driver (TH1 1507, TH2 1511, RS1 1607, RS2 1703, RS3 1709, RS4 1803,RS5 1809,19H1 1903, 19H2 1909, 20H1 VB, 21H1,versions)
- Windows 7, 8.1 Certified WHQL Driver
- Compatible with Windows Server 2008, 2008R2, 2012, 2012R2, 2016, 2019 , 2022
- Auto-download driver via Windows Update (Windows 7, 8.1, 10)
- Installer Language Support: English (default),
- For Prolific USB VID_067B&PID_2343, PID_2565,PID_2502,PID_2503
- Includes Certification Report, Driver Release Notes
- Installer supports silent install (add "/s" parameter when running program)

Driver for Linux

Download 2023/05/12 v1.0.0 366.98KB
You can update CDC-ACM patch file to support hardware flow control

PL25x3_Mac 2024/01/11 v1.2.1 534.73KB
Mac OS X Universal Binary Driver v1.2.1 (PKG file format)
For Mac OS Ventura (version 13)
For Mac OS Monterey (version 12.4)
For Mac OS Big Sur (version 11) -
For Mac OS Catalina (version 10.15) .
For Mac OS Mojave (version 10.14)
For Mac OS High Sierra (version 10.13)
For Mac OS X Sierra (version 10.12)
For Mac OS X El Capitan (version 10.11)
For Mac OS X Yosemite (version 10.10)
For Mac OS X Mavericks (version 10.9)


Download Download Download

PL2543_11GPIO_Win 2022/12/05 v1.0.0.3 1998.95KB
PL2543 11-GPIO LED Indicator Application Note Includes GPIO Test Sample Program and Source Code

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